Buspirone and dexmedetomidine synergistically reduce the shivering threshold in humans
نویسندگان
چکیده
منابع مشابه
Dexmedetomidine and meperidine additively reduce the shivering threshold in humans.
BACKGROUND AND PURPOSE Hypothermia might prove to be therapeutically beneficial in stroke victims; however, even mild hypothermia provokes vigorous shivering. Meperidine and dexmedetomidine each linearly reduce the shivering threshold (triggering core temperature) with minimal sedation. We tested the hypothesis that meperidine and dexmedetomidine synergistically reduce the shivering threshold w...
متن کاملSuppression of shivering during hypothermia using a novel drug combination in healthy volunteers.
BACKGROUND Hypothermia may be beneficial in stroke victims; however, it provokes vigorous shivering. Buspirone and dexmedetomidine each linearly reduce the shivering threshold with minimal sedation and no respiratory depression. This study tested the hypotheses that the combination of buspirone and dexmedetomidine would (1) synergistically reduce the shivering threshold, (2) synergistically red...
متن کاملNefopam and alfentanil additively reduce the shivering threshold in humans whereas nefopam and clonidine do not.
BACKGROUND Induction of therapeutic hypothermia is often complicated by shivering. Nefopam reduces the shivering threshold with minimal side effects. Consequently, nefopam is an attractive component for induction of therapeutic hypothermia. However, nefopam alone is insufficient; it will thus need to be combined with another drug. Clonidine and alfentanil each reduce the shivering threshold. Th...
متن کاملHypothermia, shivering, and dexmedetomidine
provided the original work is properly cited. CC Postoperative temperature is increasingly used to indicate the quality of anesthesia. Anesthesiologists should measure and record the body temperature of their patients perioperatively and maintain it within normal limits. Hypothermia is usually defined as a body temperature less than 36C and occurs commonly during surgery [1]. Although hypotherm...
متن کاملOndansetron does not reduce the shivering threshold in healthy volunteers.
BACKGROUND Ondansetron, a serotonin-3 receptor antagonist, reduces postoperative shivering. Drugs that reduce shivering usually impair central thermoregulatory control, and may thus be useful for preventing shivering during induction of therapeutic hypothermia. We determined, therefore, whether ondansetron reduces the major autonomic thermoregulatory response thresholds (triggering core tempera...
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ژورنال
عنوان ژورنال: Critical Care
سال: 2007
ISSN: 1364-8535
DOI: 10.1186/cc5494